SS-31 Peptide (Elamipretide) – D-Arg-Dmt-Lys-Phe-NH₂

SS-31 Peptide (Elamipretide) – D-Arg-Dmt-Lys-Phe-NH₂

SS-31 Peptide, also known as Elamipretide, is a synthetic mitochondria-targeted tetrapeptide identified by the sequence D-Arg-Dmt-Lys-Phe-NH₂. The compound has attracted considerable interest in laboratory research because of its distinctive molecular structure and its association with studies of mitochondrial membranes, cellular energy metabolism, oxidative processes, and mitochondrial function.

SS-31 belongs to a class of mitochondria-targeted peptides that has been investigated for its ability to interact with components associated with mitochondrial membranes. Unlike conventional peptides that are primarily studied for receptor-mediated activity, SS-31 has been investigated in relation to mitochondrial membrane environments and the molecular processes that occur within and around mitochondria.

SS-31 Molecular Characteristics

The molecular sequence of SS-31 is D-Arg-Dmt-Lys-Phe-NH₂. This short sequence contains four principal components, including D-arginine (D-Arg), 2′,6′-dimethyl-L-tyrosine (Dmt), lysine (Lys), and an amidated phenylalanine residue (Phe-NH₂).

The incorporation of Dmt, a modified aromatic amino acid, gives SS-31 a particularly distinctive chemical structure. Research has focused on how this structural feature contributes to the peptide’s interaction with mitochondrial membrane-associated environments. Because of its unique composition, SS-31 continues to be examined in experimental models investigating mitochondrial structure and cellular metabolism.

SS-31 and Mitochondrial Research

Mitochondria are essential cellular organelles involved in energy production and numerous metabolic processes. Their function is influenced by membrane integrity, electron transport, redox balance, and the organization of mitochondrial proteins and lipids. Consequently, mitochondrial biology has become an important area of laboratory investigation.

SS-31 Peptide has been studied in experimental research involving mitochondrial function and membrane biology. Researchers use controlled laboratory models to examine how mitochondrial-associated compounds interact with cellular systems and how changes in mitochondrial processes can be characterized.

Particular attention has been given to the relationship between SS-31 and cardiolipin, a distinctive phospholipid that is highly concentrated in the inner mitochondrial membrane. Cardiolipin plays an important structural role in mitochondrial membranes and is associated with several proteins involved in mitochondrial energy metabolism. The interaction between mitochondrial-targeted compounds and cardiolipin-containing membranes is therefore an important subject of biochemical research.

Research Applications

SS-31 is commonly investigated as a research tool in studies involving:

• Mitochondrial biology and function
• Mitochondrial membrane research
• Cellular energy metabolism
• Oxidative and redox biology
• Cardiolipin-associated processes
• Cellular stress models
• Peptide structure-function studies
• Biochemical and molecular research
• Experimental models of mitochondrial dysfunction
• Laboratory investigations of cellular metabolism

The compound can be incorporated into appropriately designed laboratory studies where mitochondrial pathways, membrane interactions, and cellular responses are being examined. Experimental results should be interpreted within the specific model, methodology, and analytical conditions used by the researcher.

Research-Grade SS-31 Peptide

Our SS-31 Peptide is supplied as a lyophilized powder to support stability during appropriate storage and laboratory handling. The material is provided in a sealed vial, and its identity and purity can be evaluated using suitable analytical techniques.

A high-purity research compound is important when reproducibility is required. By using appropriately characterized material, researchers can reduce variability associated with unwanted impurities and can better evaluate experimental observations.

SS-31 is supplied in a format suitable for qualified research laboratories. Appropriate laboratory protocols should always be followed when the material is stored, handled, analyzed, or incorporated into an experimental procedure.

Product Specifications

Specification	Details
Product Name	SS-31 Peptide
Alternative Name	Elamipretide
Peptide Sequence	D-Arg-Dmt-Lys-Phe-NH₂
Form	Lyophilized Powder
Purity	≥99%
Quantity	10 mg/vial
Storage	-20°C
Intended Application	Laboratory Research

Why Researchers Study SS-31

SS-31 has become an interesting subject within mitochondrial research because mitochondria are involved in numerous fundamental cellular processes. The peptide’s distinctive structure allows it to be studied in experimental systems where mitochondrial membranes, cardiolipin interactions, oxidative processes, and cellular energy pathways are being evaluated.

Laboratory researchers can investigate SS-31 using biochemical, cellular, and molecular approaches. Depending on the experimental design, the peptide may be examined alongside mitochondrial markers, membrane-associated components, metabolic measurements, or other analytical endpoints.

Its relatively short peptide sequence also makes SS-31 useful for research into peptide structure and function. Researchers can examine how specific amino acid characteristics influence molecular behavior and how targeted peptide structures interact with biological membrane environments.

Handling and Storage

SS-31 is supplied in lyophilized form and should be stored under the conditions recommended for the specific material. For long-term storage, the product should be maintained at -20°C unless the applicable product documentation specifies otherwise.

Exposure to unnecessary temperature fluctuations, moisture, or unsuitable environmental conditions should be minimized. Once a research compound is prepared for an experiment, appropriate laboratory procedures should be followed for handling and storage.

Researchers should consult their laboratory’s established protocols and the applicable product documentation before preparing or using the material. Repeated freeze-thaw exposure should be minimized where appropriate because peptide stability can be affected by repeated environmental changes.

Quality and Laboratory Use

Quality and consistency are important considerations when peptide materials are used for laboratory research. SS-31 should be handled as a research compound, and appropriate analytical procedures can be used to verify identity, purity, and other relevant characteristics.

Researchers are encouraged to maintain appropriate documentation for storage conditions, preparation, experimental concentration, lot information, and analytical results. These practices can help improve reproducibility and allow experimental observations to be evaluated more accurately.

Important Research Disclaimer

SS-31 Peptide (Elamipretide) is supplied strictly for laboratory and research purposes. It is not intended for human consumption, human administration, veterinary use, diagnosis, treatment, mitigation, or prevention of any disease or medical condition. This product should only be handled and studied by appropriately qualified personnel in accordance with applicable laboratory procedures, regulations, and institutional requirements.

SS-31 Peptide for Laboratory Research

With its distinctive D-Arg-Dmt-Lys-Phe-NH₂ sequence and mitochondria-targeted research profile, SS-31 Peptide provides researchers with a specialized compound for investigating mitochondrial membranes, cardiolipin-associated processes, cellular metabolism, and related biochemical pathways. Its lyophilized format and high stated purity make it suitable for appropriately controlled research environments where consistent characterization and careful laboratory handling are required.

SS-31 Peptide | Elamipretide | D-Arg-Dmt-Lys-Phe-NH₂ | ≥99% Purity | 10 mg/vial | Lyophilized Powder | Research Use Only